Choice of transcriptional direction from each D4Z4 unit is an additional requirement for DUX4 production and having FSHD

FSHD research teams in Seattle, Rochester and Leiden add to the existing FSHD model loss of heterochromatin at D4Z4 and the presence of a specific haplotype on chromosome 4 are necessary but not sufficient for DUX4 expression in PLoS ONE. Choice of transcriptional direction from each D4Z4 unit is an additional requirement for DUX4 production and having FSHD More